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Pharmacyte Biotech Inc (OTCMKTS:PMCB) Files Patent Applications to Broaden Protection of Cancer Therapy in U.S. and Worldwide

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Pharmacyte Biotech Inc (OTCMKTS:PMCB), a U.S based clinical stage biotechnology company which is engaged in the development of targeted cellular therapies for diabetes and cancer using its primary live-cell encapsulation technology, Cell-in-a-Box®, has announced filing a patent application with the United States Patent and Trademark Office (USPTO).

The application is for protecting the company’s therapy used in the treatment of cancerous tumors, including the therapy which will be used in the upcoming clinical study in locally advanced, non-metastatic, inoperable pancreatic cancer (LAPC). Additionally, the company has also filed a Patent Cooperation Treaty (PCT) application. This includes protection of it’s the company’s spread out in around 150 different countries around the world.

The two applications have a priority date from a U.S. provisional patent application which PharmaCyte filed in March of 2017.The applications for the patents specifically entails methods of treating several types of solid cancerous tumors, like those of the liver, pancreas, colon and breast using the live-cell encapsulation of genetically modified human cells which overexpress a type of the cytochrome P450 enzyme system which is normally found in the liver.

The Cell-in-a-Box® technology is used in encapsulating the cells. Used together with small doses of oxazaphosphorines, like ifosfamide, the encapsulated cells are made of PharmaCyte’s therapy for solid tumors. Additionally, the application includes use of PharmaCyte’s platform technology together with cyclophosphamide, a chemotherapy drug, which must be activated by the cytochrome P450 enzyme system. The company of hopeful that these technologies will be of benefit and help to patients who have developed resistance to chemotherapies, like gemcitabine and Abraxane®.

If granted, the new applications, will give protection for the company’s technology for a period of 20 years – up to March 2038. The biotechnology company’s pancreatic cancer treatment was issued with an orphan drug designation and listed in the registry of medicinal products for rare diseases by the FDA on December 17, 2014. Orphan drug designation will give marketing exclusivity for the company’s pancreatic cancer treatment in the U.S. for a period of 7 years after market approval by the FDA.

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